Being in this cohort framework enabled us to test if this association was independent from other factors previously linked to plasma Ab concentrations and potential mediators. To address this issue, we studied whether plasma Ab concentrations were associated with mortality risk in a subsample of the French Three-City (3C) prospective cohort study of men and women aged 65 years and more. It has been hypothesized that a high plasma amyloid level was associated with mortality. A recent report has suggested that higher dietary intakes of u3 polyunsaturated fatty acids were associated with lower plasma concentrations of Ab142 in cognitively healthy elderly subjects. Vascular risk factors including cholesterol and glycated hemoglobin (Hb A1C) are associated with higher concentrations of Ab1-42. The ratio between the two forms Ab1-40 and Ab1-42 is inversely associated with blood pressure values and the risk of hypertension in the elderly and also with depression. As described in a few studies, concentrations of amyloid peptides increase with age. Surprisingly, very little is known about the physiological “role” of amyloid in plasma.
This domain raises new questions about the role of amyloid biomarkers in terms of gaining prognosis.
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Stage, some studies have focused on determining Ab marker profile in population-based studies in subjects free of cognitive impairment and the curve of plasma Ab concentrations over a person’s lifetime and prognostic usefulness of plasma Ab biomarkers in aging populations. To improve the diagnostic criteria at an earlyġ552-5260/$ - see front matter Ó 2015 The Alzheimer’s Association. From the onset of neurodegenerative disorders throughout the temporal freeze of the AD process, it seems clear that cerebrospinal fluid (CSF) and plasma amyloid markers are highly relevant regardless of the stage of the disease: from memory complaints to loss of autonomy status and/or mortality. E-mail address: Īnd prognosis of cognitive decline in both vascular and neurodegenerative amyloidopathies. Background The role of plasma b-amyloid (Ab) biomarkers has been increasingly reported in Alzheimer’s disease (AD) diagnosis All rights reserved.Īging Mortality risks Plasma amyloid markers Cystatin C Mild cognitive impairment due to Alzheimer’s disease Frailtyġ. Conclusions: Further investigations are needed to determine precisely the pathophysiological roles of plasma Ab1-40 and cystatin C and before envisioning any future clinical applications. It was only modified when we included cystatin C levels. 03) was unveiled independently of age, educational level, vascular risk factors, diet, physical activity, cognitive impairment, or frailty status.
Results: A relationship between high plasma Ab1-40 concentrations and risk of mortality (hazards ratio, 1.15 95% confidence interval, 1.01–1.31, P 5. Associations between plasma Ab and mortality were assessed with the Cox regression model with delayed entry including various potential confounding factors and testing possible mediators. Methods: Analyses were based on 1254 participants randomly selected from the initial 3C cohort stratified by center, sex, and age in the context of a nested case-cohort study to investigate biological variables. Plasma b-amyloid 40 levels are positively associated with mortality risks in the elderly Audrey Gabellea,b, Susanna Schraenc,d,e, Laure-Anne Gutierreza,f, Cecile Paysa,f, Olivier Rouaudg, Luc Bueec,d,e, Jacques Touchona,f, Catherine Helmerh, Jean-Charles Lambertd,i,j,k, Claudine Berra,f,l,* aĭepartment of Neurology, Centre Memoire Ressources Recherche Languedoc-Roussillon, CHRU Gui de Chauliac Hospital, Montpellier, France b University Montpellier 1, Montpellier, France c Universite Droit et Sante de Lille, Lille, France d CHRU de Lille, Lille, France e INSERM UMR837, Lille, France f INSERM U1061, H^opital La Colombiere, Montpellier, France g Department of Neurology, Centre Memoire Ressources Recherche, CHRU Dijon, Dijon, France h INSERM 897, ISPED, Victor Segalen University, Bordeaux, France i INSERM U744, Lille, France j Institut Pasteur de Lille, Lille, France k Universite de Lille Nord de France, Lille, France l Universite Montpellier 1, H^opital La Colombiere, Montpellier, Franceīackground: We evaluated if plasma b-amyloid (Ab) levels were associated with mortality risks in a subsample of the French Three-City (3C) prospective cohort study.
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